In the inflammatory gastroenterology trial in which MediServ participates, most patients are now in the open-label phase. For the Rheumatology study the anticipated number of patients is almost included. In the meantime also patient number 2 and 3 are included in the gastroenterological oncology study. The authorities has approved the start for the another inflammatory gastroenterology trial. PSN has a number of new projects in the pipeline, for example a new trial with the same investigational drug as used at the first study mentioned; this time for a paediatric indication. Furthermore a quotation is done for a trial with adult patients with a certain metabolic disorder, and also for a trial with a medical device in a neurological disease.
Information from the Field
TEST ON PROSTATE CANCER DOES NOT SAVE LIFES
Men of about sixty years old who did a prostate cancer test (PSA-test), do not live longer than men who didn’t. These are the results of a large scale investigation in England. The PSA-test on prostate cancer is controversial. It is a simple blood test which became fashionable in the nineties. The outcome of the test at most provides information about an increased chance on prostate cancer, so further research is inidcated. The prostate is the gland at the end of the bladder which produces a part of the ejaculation fluid. Prostate cancer is the most common cancer in men, in the Netherlands 11.700 new patients per year, mostly seniors. And 2.800 men die of prostate cancer per year. That means that more men die with than by prostate cancer. That relatively good news is the underlying problem of the PSA-test: many tumours which come to light will never cause troubles (or death). When patients are treated often annoying side effects occur, such as incontinence and impotence. The PSA-test is never offered as a screening method. But, according to the actual guidelines men can get it when they ask for; this after being properly informed about the pro’s and con’s. The question is whether the guidelines need to be adjusted based on this English investigation.
Source: NRC Scientific supplement, 07.03.2018.
OLDER THAN 100 YEARS OLD? THAT IS THANKS TO THE MOTHER
Some people become old, very old. Scientists in Leiden investigate how this is possible. They followed for years 421 families having many members older than 90 years. In these families a longevity is hereditary and now it seems that the phenomenon is passed along by the female line. Mothers who become older than 95 years, pass on a high life expectancy to their children. The age of the father doesn’t matter. The life expectancy of every Dutchman has increased the last years due to better healthcare and nutrition. However, a small part of the people become very old because of the good genes. Investigators assume that these genes are in the mitochondrial DNA. Children always inherit this DNA from their mother. Final proof of this is not still there yet.
Source: NRC Scientific supplement, 03.04.2018.